Nizoral is the OTC anti-dandruff shampoo people turn to when lighter formulas fall short: its active ingredient is ketoconazole 1%, used about twice a week per the label. Follow the package directions, alternate with a gentle shampoo since it can be drying, and see a dermatologist for persistent or severe symptoms. Informational, not medical advice.

Best for Persistent Flakes
Nizoral Anti-Dandruff Shampoo (Ketoconazole 1%)
An OTC ketoconazole shampoo that many people reach for when gentler anti-flake washes aren't enough — used twice weekly per the label. For persistent symptoms, see a dermatologist.
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- Active Ketoconazole 1%
- Use 2x/week per label
- Note Follow package directions
Specifications
| Active | Ketoconazole 1% |
|---|---|
| Use | 2x/week per label |
| Note | Follow package directions |
Pros and cons
What we like
- Active ketoconazole 1%
- Used just twice a week
- Widely recommended for stubborn flakes
What we don't
- Can be drying
- Medicinal, not a daily shampoo